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pentobarbital will lower the level or influence of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of CYP3A4 inducers might decrease sufentanil degrees